Biological & pharmaceutical bulletin

Harmine lengthens the daily rhythm of the brain’s main biological clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Harmine significantly lengthened the circadian period of PER2::LUC expression in various cell types.

  • The circadian clock is a system that regulates biological rhythms in most organisms.
  • Harmine has been found to increase the stability of the PER2 protein in neuronal cells and SCN slices.
  • While harmine lengthened the circadian period, it did not induce the short-term expression of specific clock genes in embryonic fibroblasts.
  • The effects of harmine were observed in NIH 3T3 fibroblasts, neuronal cells differentiated from progenitor cells, and SCN slices from PER2::LUC mice.
  • These findings suggest that harmine may extend the circadian period by enhancing the stability of the PER2 protein.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Aug '17
Daily Calcium Rhythms in the Brain's Internal Clock: Independent Cell Patterns and Network Influence
top 20% journal
cited by 68 papers
research support, n.i.h., extramural
Mar '17
NF-κB signalling affects immune responses but not basic timekeeping in the mouse circadian clock
cited by 13 papers
research support, non-u.s. gov't
Jan '12
Valproic acid changes the timing of daily Period2 gene activity
cited by 83 papers
research support, non-u.s. gov't
Jul '15
Specific Ion Channels Control Daily Timing of a Key Protein in the Brain’s Biological Clock
cited by 22 papers
research support, n.i.h., extramural
Apr '14
The Tau mutation in casein kinase 1ε changes the body’s daily clock by controlling Period1 and Period2 proteins
cited by 43 papers
research support, non-u.s. gov't
Jun '12
Different roles of internal clock genes in the eye's rhythm system and the brain's master clock
top 30% journal
cited by 47 papers
research support, n.i.h., extramural
Aug '13
Long-term alcohol use disrupts the liver’s internal clock and daily metabolism rhythms but not the brain’s main timekeeper
top 30% journal
cited by 74 papers
research support, n.i.h., extramural
Mar '16
Lithium's effects on daily biological rhythms in skin cells and brain clock tissue from mice lacking Cry genes
cited by 27 papers
research support, n.i.h., extramural
Oct '18
Two linked daily rhythms control Bmal1 and Per2 gene activity in the mouse brain's internal clock
top 20% journal
cited by 12 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
yesterday7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
1 week ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
2 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
3 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
4 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
6 weeks ago7 studies
issue #36
Night owls show 77% higher risk of job burnout among firefighters
8 weeks ago7 studies
issue #35
Bacteria exposure resets your internal clock independently of immune responses
9 weeks ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
10 weeks ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
11 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief