NF‐κB signalling is involved in immune‐modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock

Chronic treatment with the NF-κB inhibitor PDTC did not impact circadian or diurnal rhythms.

• The suprachiasmatic nucleus (SCN) is identified as the master pacemaker for circadian rhythms.
• Serum shocked fibroblasts exhibited rhythmic nuclear localization of the NF-κB component p65.
• No circadian changes were observed in the expression of NF-κB components in the SCN.
• Peripheral lipopolysaccharide treatment increased NF-κB component expression in the SCN.
• In vitro SCN slice cultures showed that NF-κB inhibitors did not significantly alter rhythmic PER2::LUC expression.
• Older mice exhibited increased amplitude of rhythmic PER2::LUC expression following PDTC treatment.

AI simplified