Heme reversibly damps PERIOD2 rhythms in mouse suprachiasmatic nucleus explants

Aug 25, 2009Neuroscience

Heme temporarily reduces daily rhythms in the brain's internal clock area of mice

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Abstract

Ferric heme (hemin) at concentrations of 3-100 microM dampened luminescence rhythms in mouse SCN explants expressing a PER2::LUCIFERASE fusion protein.

  • Heme may modulate the function of feedback loop components within the circadian system.
  • Inhibitors of heme oxygenases produced effects similar to heme on PER2 rhythms.
  • Heme's effects on luminescence rhythms were specific to certain tissues, with no significant impact observed in thymus and esophagus explants.
  • The degradation products of heme likely do not contribute to its effects on circadian rhythms.
  • Inhibition of heme synthesis lengthened the circadian period of SCN PER2::LUC rhythms by approximately one hour.

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