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A tale of the good and bad: Cell senescence in bone homeostasis and disease
The role of aging cells in keeping bones healthy and causing bone diseases
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Abstract
Cellular senescence has been linked to both aging and important physiological functions during development and tissue remodeling.
- Cellular senescence is characterized by diverse and dynamic states, rather than a single irreversible process.
- The senescence-associated secretory phenotype (SASP) plays a critical role in mediating the effects of senescent cells.
- Senescent cells contribute to essential functions in embryonic development and influence bone growth during puberty.
- Accumulating evidence suggests that cellular senescence may have both beneficial and detrimental effects on bone health across various life stages.
- Senescence is associated with maintaining bone homeostasis and may influence the development of age-related osteoporosis.
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