Targeting Cell Senescence for the Treatment of Age-Related Bone Loss

Cellular senescence is associated with age-related bone loss and is influenced by various stressors.

• Cell senescence is an irreversible state of cell cycle arrest triggered by factors such as oxidative stress and DNA damage.
• The senescence-associated secretory phenotype (SASP) released by senescent cells can have harmful effects on surrounding cells and tissues.
• Aging leads to the senescence of multiple cell types in the bone environment, particularly osteocytes and myeloid cells.
• Targeting senescent cells may help enhance bone formation and reduce bone loss in aging individuals.
• Improving bone quality and function could be possible by addressing cellular senescence in aging and disease contexts.

AI simplified