How daily biological clocks and cell oxidation cycles interact

Circadian rhythms may be influenced by non-transcriptional oscillations such as metabolic and redox cycles.

• The circadian clock helps organisms coordinate behavior and physiology with the solar cycle.
• Current models primarily focus on transcriptional/translational feedback loops for circadian timekeeping.
• Recent findings indicate that non-transcriptional oscillations, particularly involving metabolic and redox cycles, may be crucial.
• Peroxiredoxins, which are antioxidant proteins, show rhythmic oxidation patterns on a circadian scale across various species.
• The close relationship between circadian rhythms and redox pathways suggests a potential conserved mechanism for timekeeping.

Simplified