Full text is available at the source.
Abstract
Practical guidelines for identifying senescent cells in vivo are provided through the 'minimum information for cellular senescence experimentation in vivo' (MICSE).
- Cellular senescence is associated with stable cell-cycle arrest and a hypersecretory state in response to stress.
- Senescence has diverse roles in biological processes, including tissue repair and chronic disease.
- New tools for studying senescence in living organisms may help uncover its physiological and pathological roles.
- A lack of specific markers has hindered the identification and characterization of senescent cells in various tissues.
- The MICSE guidelines offer an overview of senescence markers across different species and tissues to aid in research.
Simplified