SenNet recommendations for detecting senescent cells in different tissues

Cellular senescence may play both beneficial and detrimental roles in various biological processes across humans, rodents, and other species.

• Cellular senescence is associated with a permanent stop in cell division and has been linked to different biological processes.
• Existing knowledge largely stems from tissue culture studies, where cells are forced into senescence.
• Senescent cells are rare in tissues, making them challenging to identify and study.
• Fully differentiated, non-dividing cells can also exhibit features of senescence.
• Recommendations for detecting senescent cells in tissues are based on a review of senescence markers found in 14 tissues in mice and humans.
• Recent advances include the identification of molecular signatures and morphological characteristics of senescent cells.

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