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Cellular senescence: mechanisms and relevance to cancer and aging
How cell aging works and its importance for cancer and getting older
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Abstract
is an irreversible cell cycle arrest that may contribute to aging and age-related diseases.
- Senescence is induced by stresses like telomere shortening and oncogene activation.
- While it acts as a tumor suppressor mechanism, senescent stromal cells can promote tumor progression.
- Accumulation of senescent cells over time is associated with aging and related diseases.
- Senescent cells secrete bioactive molecules, including inflammatory cytokines and chemokines.
- The intracellular signaling pathways that cause senescent phenotypes are not fully understood.
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