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Abstract
Senescent cells secrete a variety of substances known as the senescence-associated secretory phenotype (SASP).
- SASP includes cytokines, chemokines, proteases, growth factors, and enzymes that affect tissue remodeling.
- It reinforces cell cycle arrest in senescent cells and may recruit immune cells for clearing potentially cancerous cells.
- SASP can also induce chronic inflammation, which may lead to tissue damage and promote tumor cell growth.
- The components and effects of SASP are highly variable and depend on the surrounding context.
- Regulation of SASP occurs at various biological levels, involving changes in gene expression and protein production.
- Identified SASP modulators could have potential clinical applications, warranting further research.
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