Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging

Senescent cells secrete a variety of substances known as the senescence-associated secretory phenotype (SASP).

• SASP includes cytokines, chemokines, proteases, growth factors, and enzymes that affect tissue remodeling.
• It reinforces cell cycle arrest in senescent cells and may recruit immune cells for clearing potentially cancerous cells.
• SASP can also induce chronic inflammation, which may lead to tissue damage and promote tumor cell growth.
• The components and effects of SASP are highly variable and depend on the surrounding context.
• Regulation of SASP occurs at various biological levels, involving changes in gene expression and protein production.
• Identified SASP modulators could have potential clinical applications, warranting further research.

AI simplified