Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)

Senescent cells develop a dynamic pro-inflammatory secretome known as the senescence-associated secretory phenotype (SASP).

• The SASP influences the behavior of nearby cells, affecting their growth and movement.
• It may reinforce or trigger senescence in surrounding cells and alter immune cell activity.
• SASP composition changes over time, with multiple waves of secreted factors interacting.
• The maturity of the senescence phenotype and its stable state is still debated.
• Experimental methods are being developed to generate and analyze SASP over time.

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