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Abstract
Cellular senescence and the senescence-associated secretory phenotype (SASP) may contribute to renal fibrosis in chronic kidney disease.
- Renal fibrosis plays a significant role in the progression of chronic kidney disease and end-stage renal disease.
- A complex interplay exists between cellular senescence, the SASP, and renal fibrosis.
- The SASP is associated with irreversible renal fibrosis through mechanisms like fibroblast activation and abnormal extracellular matrix accumulation.
- Inhibiting cellular senescence and the SASP could be a potential strategy for preventing and treating renal fibrosis.
- Promising therapeutic approaches include targeting the SASP, caloric restriction, and novel stem cell regeneration therapies.
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