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Abstract
Dysfunction of the glymphatic system may relate to the occurrence of Alzheimer's disease.
- Imbalance of Aβ and tau protein production and clearance is a key factor in neuron degeneration and cognitive disorders.
- Microinfarcts in the aging brain dramatically increase metabolic waste generation and hinder glymphatic system operation.
- Disruption of microvascular and microstructural tissue integrity due to microinfarcts leads to Aβ deposition and tau phosphorylation.
- Neurofibrillary tangles formed from Aβ and tau are associated with the pathology of Alzheimer's disease.
- Enhancing glymphatic system function after microinfarcts could serve as a potential new strategy for Alzheimer's disease prevention and treatment.
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