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Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus
Reduced Brain Waste Clearance in Alzheimer's Disease and Normal Pressure Hydrocephalus
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Abstract
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH).
- iNPH is characterized by an expansion of the cerebrospinal fluid-filled brain ventricles.
- Both iNPH and Alzheimer's disease (AD) are associated with sleep disturbances and the build-up of metabolic wastes.
- The presence of amyloid-β (Aβ) plaques and reactive astrogliosis is noted in both conditions.
- Mislocalization of astrocyte aquaporin-4 (AQP4) occurs in iNPH and AD.
- Impaired glymphatic function may contribute to the pathology observed in both iNPH and AD.
- Investigating glymphatic system biology could help develop strategies to enhance brain health.
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