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Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease
Enlarged fluid spaces around blood vessels in Alzheimer's and vascular dementia suggest a role for support cells specific to Alzheimer's
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Abstract
Both Alzheimer's disease (AD) and mixed dementia groups showed significantly increased enlargement of the perivascular space (ePVS) compared to cognitively intact subjects.
- Increased global expression of aquaporin-4 (AQP4) was observed in the AD group compared to both control and mixed dementia groups.
- A qualitative reduction in the perivascular localization of AQP4 was found specifically in the AD group.
- The burden of ePVS was associated with the presence of tau and amyloid-β pathology among the studied cases.
- Findings suggest differences in ePVS related to Alzheimer's disease and vascular dementia.
- The study provides new insights into the potential role of astroglial pathology in ePVS.
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