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Astroglial water channel aquaporin 4-mediated glymphatic clearance function: A determined factor for time-sensitive treatment of aerobic exercise in patients with Alzheimer’s disease
Brain cell water channels may affect how exercise timing helps clear waste in Alzheimer’s patients
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Abstract
Aerobic exercise may enhance the clearance of β-amyloid from the brain through the aquaporin 4 (AQP4) protein.
- There are currently no effective drug therapies for Alzheimer's disease (AD).
- Aerobic exercise has been shown to have time-sensitive benefits in the prevention and treatment of AD.
- AQP4 is involved in the glymphatic system that clears interstitial solutes, including β-amyloid, from the brain.
- Voluntary exercise has been demonstrated to promote glymphatic clearance function in mice.
- Glymphatic function decreases in mid- to late-stage AD due to loss of AQP4 polarity distribution.
- AQP4-mediated glymphatic clearance may be critical for the efficacy of aerobic exercise in treating AD.
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