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Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?
Aquaporin4 Levels in Spinal Fluid as a Possible Sign of Waste Clearance System Involvement in Brain Diseases
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Abstract
Cerebrospinal fluid AQP4 levels were significantly reduced in 11 patients with Alzheimer's disease compared to controls.
- AQP4 is a water channel protein located at astrocyte foot processes, associated with the glymphatic system.
- Reduced AQP4 levels in Alzheimer's disease patients suggest a potential link to neurodegenerative processes.
- A trend toward reduced AQP4 levels was observed in patients with normal pressure hydrocephalus.
- A correlation exists between AQP4 levels and amyloid-Ī² levels in cerebrospinal fluid.
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