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Synthesis of new chalcones and pyrimidine derivatives as antidiabetic agents for type 2 diabetes mellitus: In vitro and in vivo studies
New chalcone and pyrimidine compounds as potential treatments for type 2 diabetes tested in lab and animal studies
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Abstract
Fifty-four rats were divided into nine groups to evaluate the antidiabetic activities of synthesized compounds.
- Different chalcones were synthesized and reacted with metformin to produce new pyrimidine derivatives.
- In vitro assays indicated that compounds 1c and 2c had the strongest glucose uptake activities.
- Compound 1a exhibited the highest affinity with α-glucosidase, while compound 2c showed strong binding to dipeptidyl peptidase 4 and protein tyrosine phosphatase 1B.
- Significant inhibitory effects against α-amylase and α-glucosidase were observed for compounds 1a, 1c, and 2c.
- In vivo studies demonstrated that compounds 1c and 2c have significant antidiabetic effects in streptozotocin-induced diabetic rats.
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