Using chemical biology to understand how plant internal clocks work at the molecular level

Chemical modulators can influence the circadian clock in plants by targeting transcription-translation feedback loops (TTFL).

• Circadian clocks help plants adjust their physiological activities based on day-night and seasonal changes.
• Transcription-translation feedback loops (TTFL) are essential for the functioning of the Arabidopsis circadian clock.
• Recent advancements in chemical biology have enabled the use of small molecules to disrupt plant circadian clock mechanisms.
• Small molecule clock modulators have revealed the significance of post-translational modifications in clock regulation.
• These modulators also play a role in influencing the timing of flowering in plants.

Simplified