Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression

Mar 27, 2012Psychoneuroendocrinology

Links between childhood trauma and stress system function in borderline personality disorder and major depression

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Abstract

BPD and MDD patients exhibited both enhanced cortisol concentrations compared to healthy controls.

Cortisol levels were higher in patients with borderline personality disorder (BPD) and major depressive disorder (MDD) before and after a dexamethasone test.
A positive correlation was found between cortisol levels and a history of childhood trauma, current dissociative symptoms, and the severity of borderline and depressive symptoms.
Some aspects of early trauma were linked to cortisol release, while adult psychopathology did not significantly contribute to cortisol levels in regression analyses.
HPA dysfunctions may be more related to childhood trauma than to adult mental health conditions.

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BACKGROUND: Alterations of the hypothalamus-pituitary-adrenal (HPA) axis are hallmarks in major depressive disorder (MDD) and there is some evidence about similar patterns in borderline personality disorder (BPD). This study examines HPA axis abnormalities with respect to clinical characteristics in both BPD (n=24) and MDD patients (n=33) as well as in healthy control participants (n=41).

METHOD: A 0.5mg dexamethasone suppression test was administered to evaluate basal cortisol release and HPA feedback sensitivity via salivary cortisol. Traumatic experiences in childhood as well as severity of borderline and depressive symptom severity and dissociation were obtained by self-report questionnaires.

RESULTS: Compared to the healthy control group, BPD and MDD patients exhibited both enhanced cortisol concentrations before and after the administration of 0.5mg dexamethasone. Higher cortisol levels were positively correlated to a history of childhood trauma, current dissociative symptoms and severity of borderline and depressive symptoms. Regression analyses revealed that some aspects of early trauma were associated with cortisol release before and after dexamethasone, whereas psychopathology did not contribute to the regression model.

CONCLUSIONS: HPA dysfunctions appear to be related rather to childhood trauma than to psychopathology in adulthood. Exposure to childhood trauma may contribute to long-lasting alterations in HPA activity and might enhance the risk for the development of later mental disorder.

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Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression

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