We can’t show the full text here under this license.
Key points for detecting gut bacteria that break down choline and carnitine
Updated
Abstract
Bacterial formation of trimethylamine (TMA) has been linked to cardiovascular disease.
- Certain bacteria in the human gut may convert dietary choline and carnitine into TMA.
- Key metabolic pathways for TMA production include anaerobic choline-TMA lyase, CutC, and aerobic carnitine monooxygenase, CntA.
- Identification of these enzymes allows for the use of bioinformatics to screen bacterial genomes and gut metagenomes.
- This review highlights methods for determining which bacteria are responsible for TMA formation in the human gut.
Simplified