We can’t show the full text here under this license. Use the link below to read it at the source.
The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit
The SNR1/SNF5 subunit controls DNA packaging and mRNA processing functions of the Brahma (SWI/SNF) complex
AI simplified
Abstract
Incorporation of a loss of function SNR1 subunit led to alterations in RNA polymerase elongation and pre-mRNA splicing regulation.
- Nucleosome remodeling by the is essential for regulated gene expression.
- The Drosophila Brahma (Brm) SWI/SNF complex responds to ecdysone hormone signaling during development.
- Loss of chromatin remodeling function is linked to developmental abnormalities and aggressive cancers.
- plays a unique role in regulating target gene expression by restricting BRM-dependent nucleosome remodeling.
- Changes in chromatin accessibility of hormone-regulated genes were observed with SNR1 dysfunction.
AI simplified
Key numbers
79-fold
Increase in spliced product
Measured in developmental stages where transcripts are detected.
6-fold
Reduction in 3′ transcript
Observed in early pupae with RNAi depletion of NELF.