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Chronic citalopram treatment ameliorates depressive behavior associated with light at night.
Long-term citalopram treatment reduces depression-like behavior linked to exposure to light at night
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Abstract
Chronic exposure to dim light at night (5 lux) may provoke depressive-like behavior in female hamsters.
- Depressive-like behaviors were observed in hamsters exposed to dim light at night.
- Citalopram treatment improved depressive-like behavior in hamsters exposed to dim light but not in those on a standard light-dark cycle.
- Dendritic spine density in the hippocampal CA1 region was moderately improved by citalopram but not fully restored.
- The findings support the use of this model for studying depression linked to circadian disruption.
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