Long-term low-fat diet improves heart and metabolism health depending on the CLOCK gene in heart disease patients

In a study of 897 patients, significant gene-diet interactions were found between the rs4580704 SNP and a low-fat diet.

• Major allele carriers (C/C) of the rs4580704 SNP showed a greater decrease in high sensitivity C-reactive protein compared to minor allele carriers (G/G + C/G).
• The decrease in inflammation markers was statistically significant (p < 0.001).
• Carriers of the major allele also had a significant increase in the HDL/apolipoprotein A1 ratio (p = 0.029).
• No other interactions between CLOCK SNPs and diets were identified in the study.
• The findings suggest that the rs4580704 SNP may influence the effectiveness of a low-fat diet on inflammation and lipid profiles in patients with coronary heart disease.

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