Chronic jetlag-induced alterations in pancreatic diurnal gene expression

Approximately 5.4% of the pancreatic transcriptome was found to be rhythmic under normal conditions.

• Chronic jetlag exposure reduced the rhythmic transcripts in the pancreatic transcriptome to about 3.6%.
• Most core clock genes, which regulate circadian functions, exhibited a phase shift in their peak expression timing.
• Over 95% of rhythmically expressed pancreatic genes also showed a phase shift, many of which are significant for metabolism.
• Several pancreas-specific genes linked to exocrine secretion and insulin signaling displayed rhythmic expression and phase shifts following chronic jetlag.
• Phase differences persisted even 9 days after returning to a regular light-dark cycle, suggesting difficulty in readjusting to new rhythms.

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