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Chronic jetlag reprograms gene expression in the colonic smooth muscle layer inducing diurnal rhythmicity in the effect of bile acids on colonic contractility
Chronic jetlag changes gene activity in the colon’s muscle layer, causing daily rhythms in how bile acids affect colon movement
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Abstract
Chronic jetlag abolished the rhythmicity in serum bile acid levels.
- This disruption was associated with a phase-shift in diurnal clock gene expression in colonic smooth muscle.
- A rhythm in the expression of the bile acid receptor GPBAR1 was induced in the colonic smooth muscle layer.
- The effect of taurodeoxycholic acid (TDCA) on neural colonic contractions exhibited a rhythm that peaked alongside GPBAR1 expression.
- In contrast, no rhythmic effect was observed with deoxycholic acid on colonic contractions.
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