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Chronodisruption by chronic jetlag impacts metabolic and gastrointestinal homeostasis in male mice
Chronic jetlag disrupts daily rhythms and affects metabolism and gut health in male mice
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Abstract
Chronic jetlag increased body weight gain and disrupted the day/night food intake pattern.
- Chronic jetlag led to a phase-delay in the rhythm of faecal short-chain fatty acids (SCFAs).
- The shift in SCFA levels paralleled changes in the expression of clock genes in the colonic mucosa.
- Jetlag abolished rhythmic patterns in the expression of certain gut hormones, including Tnfα and proglucagon.
- A dampening of plasma glucagon-like peptide-1 levels was observed, while ghrelin levels remained unchanged.
- In genetically modified mice lacking a functional circadian clock, rhythms in ghrelin expression were lost, indicating a potential link between circadian rhythms and hormone regulation.
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