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The circadian clock regulates the diurnal levels of microbial short‐chain fatty acids and their rhythmic effects on colon contractility in mice
The daily body clock controls gut bacteria acids and their daily effects on colon movement in mice
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Abstract
Diurnal fluctuations in faecal short-chain fatty acid (SCFA) concentrations peak 4 hours after lights on.
- Faecal SCFA concentrations show a rhythm synchronized with the expression of the FFAR2/3 receptors in colonic muscle.
- The inhibitory effect of SCFAs on colonic neural contractions also displays a diurnal rhythm that aligns with SCFA levels and receptor expression.
- Excitatory neural responses and acetylcholine-induced contractions in colonic smooth muscle do not exhibit a diurnal rhythm.
- In mice lacking the core clock gene Bmal1, fluctuations in faecal SCFA levels and related receptor expression are absent.
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