Ovariectomized rats were heavier and had greater food intake compared to sham-operated rats.
Ovariectomized rats exhibited increased organ masses relative to body mass compared to sham-operated rats.
(CPS) rats showed greater water intake and reduced liver mass than control light rats.
Ovariectomized rats had lower glucose concentration, while CPS rats exhibited higher glucose concentration during the oral glucose tolerance test.
CPS rats demonstrated higher systolic blood pressure compared to control light rats.
No interaction between ovariectomy and CPS was observed regarding cardiometabolic parameters.
Simplified
Postmenopausal shift workers face increased cardiometabolic risk due to estrogen decline and shift work-induced circadian misalignment. Yet, their combined effects remain poorly understood, especially in hypertensive individuals. This study investigated whether circadian misalignment worsens cardiometabolic parameters in a hypertensive ovariectomized rat model. Female (SHR) were ovariectomized or sham-operated (7-week-old), and then exposed to a (CPS) protocol or a control light schedule for 10 weeks ( = 9 per group). Measurements included body mass, food and water intake, blood pressure (BP), fasting glucose, glucose tolerance, organ masses, and low-density lipoprotein (LDL) concentration. Ovariectomized rats were heavier and had greater food intake and organ masses than sham-operated rats. However, food intake and organ masses were reduced relative to body mass. CPS rats had greater water intake and reduced liver mass than control light rats. In addition, ovariectomized rats showed lower glucose concentration than sham-operated rats, whereas CPS rats showed higher glucose concentration than control light rats during the oral glucose tolerance test. Moreover, the CPS rats had higher systolic BP. The LDL and fasting glucose concentrations were similar. No interaction between ovariectomy and CPS was observed. These findings suggest that estrogen deficiency increases body mass, but does not worsen cardiometabolic parameters in female SHR. CPS-induced circadian misalignment altered water intake, liver mass, systolic BP and glucose tolerance in the CPS condition in female SHR. This study was unable to monitor physiological or behavioral indicators to confirm circadian misalignment by the CPS protocol. However, the findings provide novel insights into how CPSs independently impair cardiometabolic outcomes in female SHR, with implications for understanding risk in postmenopausal shift workers. n
Key numbers
0.688
Increase in Systolic BP
rats vs. control light rats
0.394
Lower Glucose Concentration
rats vs. control light rats during OGTT
41.99
Higher Body Mass in Ovariectomized Rats
Comparison of body mass between ovariectomized and sham-operated rats
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Conflict of Interest StatementThe authors have no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
