Effects of a chronic reduction of short-wavelength light input on melatonin and sleep patterns in humans: Evidence for adaptation

Chronic exposure to reduced blue light for two weeks increased sensitivity to melatonin suppression in healthy young subjects (n = 15).

• Wearing soft orange contact lenses resulted in a reduction of the light's melatonin-suppressing effect.
• After two weeks of reduced exposure to short-wavelength light, sensitivity to melatonin suppression increased.
• The response to melatonin suppression normalized as if exposed to regular light.
• No significant changes were observed in the timing or amplitude of melatonin rhythms following reduced blue light exposure.
• Effects on sleep parameters were limited, suggesting minimal impact on overall sleep quality.

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