Long-term semaglutide treatment reduces cue-driven cocaine relapse and repetitive cocaine behaviors in male and female rats

Semaglutide reduced cue-induced reinstatement and cocaine-induced stereotypy in rats after a 30-day abstinence period.

• Daily administration of semaglutide was provided to rats following cocaine self-administration.
• Cue-induced reinstatement of cocaine-seeking behavior was diminished with semaglutide treatment.
• Cocaine-induced stereotypy, which refers to repetitive behaviors associated with cocaine use, was also reduced.
• Operant responding increased following cocaine priming despite the effects of semaglutide.

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