Chronic lack of sleep disrupts energy balance controlled by the brain's internal clock signals in mice

Chronic sleep deprivation in mice led to significant changes in energy metabolism, as evidenced by altered expressions of specific neuropeptides.

• Chronic sleep deprivation caused abnormal levels of AgRP/NPY and POMC in mice.
• This disruption is linked to impaired JAK/STAT3 signaling pathways and reduced energy expenditure.
• Overexpression of BMAL1 in the suprachiasmatic nucleus may counteract these effects.
• The findings suggest that sleep deprivation could directly affect energy balance through BMAL1 expression in the master circadian clock.

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