Full text is available at the source.
Chronic Social Defeat Stress Shifts Peripheral Circadian Clocks in Male Mice in a Tissue-Specific and Time-of-Day Dependent Fashion
Long-term Social Stress Changes Body Clocks in Male Mice Differently Across Tissues and Times of Day
AI simplified
Abstract
Social defeat stress caused a phase delay of several hours in the rhythm of PER2 expression in lung and kidney tissues.
- Acute and chronic social defeat stress were tested in mice to observe effects on peripheral circadian clocks.
- Phase delays in PER2 expression rhythms were stronger after chronic stress exposure compared to acute stress.
- Significant rhythm shifts occurred only when stress was administered during the late dark phase, not in the early dark phase.
- No significant shifts in PER2 rhythms were observed in liver and white adipose tissue, indicating tissue-specific responses to stress.
- Cumulative effects of chronic stress may be necessary to produce these shifts in peripheral clocks.
AI simplified