Melatonin Does Not Affect the Stress-Induced Phase Shifts of Peripheral Clocks in Male Mice

Melatonin treatment did not affect peripheral circadian rhythms or mitigate stress-induced changes in activity in male mice.

• Repeated or chronic stress can alter the timing of peripheral circadian rhythms.
• Melatonin may play a role in synchronizing these rhythms but was ineffective in this context.
• Night-restricted melatonin increased activity rhythm alignment with a shifted light-dark cycle but did not prevent activity reduction due to stress.
• Stress led to phase delays in peripheral clocks located in the pituitary, lung, and kidney.
• Dexamethasone affected circadian rhythms in various tissues, while melatonin did not influence these rhythms or mitigate dexamethasone's effects.

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