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CHRONO regulates the circadian clock via the REV-ERBα – BMAL1 loop
CHRONO controls the body’s daily clock through the REV-ERBα and BMAL1 feedback loop
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Abstract
CHRONO regulates the circadian period by acting as a on JUN/FOS complexes.
- The 's period length is crucial for maintaining homeostasis in organisms.
- CHRONO's role extends beyond the classical BMAL1/CLOCK complexes, influencing JUN/FOS complex activity.
- CHRONO differentially regulates the expression of REV-ERBα and REV-ERBβ, which in turn affects BMAL1 levels.
- A mathematical model supports the conclusion that CHRONO impacts both REV-ERBα and BMAL1 to modulate the circadian period.
- CHRONO is found to cycle in most mammalian tissues, suggesting a wide physiological relevance.
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Key numbers
1 hour
Circadian Period Extension
CHRONO knockout leads to a prolonged circadian period.