Full text is available at the source.
Abstract
Chrono-modulated drug delivery systems (CDDS) may enhance chemotherapy efficacy while minimizing toxicity.
- CDDS align drug release with circadian rhythms, potentially improving pharmacokinetics and pharmacodynamics.
- Temporal fluctuations in drug metabolism and immune function are leveraged to refine treatment outcomes.
- Innovations such as stimuli-responsive hydrogels and programmable devices enable precise drug timing.
- Evaluation of various delivery platforms suggests improved therapeutic indices and reduced side effects.
- Challenges include regulatory hurdles and variability in individual circadian patterns.
- Future approaches may integrate wearable biosensors and AI to enhance clinical application.
Simplified