Chronotype is differentially associated with lifetime mood and panic-agoraphobic spectrum symptoms in patients with bipolar disorder and healthy controls

Self-reported evening chronotype is associated with higher depressive symptoms in both healthy controls and patients with bipolar disorder.

• Evening chronotype as measured by the Morningness-Eveningness Questionnaire is linked to increased depressive scores in both healthy controls and bipolar disorder patients.
• Both evening and morning chronotypes show an association with higher panic-agoraphobic symptoms specifically in bipolar disorder patients.
• Morning chronotype measured through actigraphy is correlated with elevated depressive scores in healthy controls.
• Discrepancies between self-reported and actigraphic-based circadian typologies are associated with depressive symptoms in healthy controls.

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