Chronotype and substance use disorder: A systematic review with meta-analysis on the impact of circadian misalignment on psychopathology and clinical course

Jun 26, 2025Sleep medicine reviews

Body Clock Types and Substance Use Disorder: How Misaligned Daily Rhythms Relate to Mental Health and Illness Progress

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Abstract

Individuals with evening preference have a 1.55 times higher likelihood of being diagnosed with a substance use disorder compared to those with morning preference.

  • Circadian rhythms influence important biological functions such as sleep and mood.
  • Chronotype, or individual differences in circadian preference, may impact the risk of psychiatric disorders.
  • Evening preference is linked to emotional dysregulation and impulsive behavior.
  • The review synthesized clinical literature on the relationship between chronotype and substance use disorders.
  • Evidence shows evening preference is associated with earlier onset and greater symptom severity of substance use disorders.
  • Poorer treatment outcomes are also reported for individuals with evening preference.

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