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Circadian clock control of breast cancer hallmarks: molecular mechanisms and therapeutic implications
How the Body’s Internal Clock May Influence Key Features of Breast Cancer and Treatment Options
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Abstract
Circadian disruption is associated with an increased risk of cancer, particularly in night-shift workers and those experiencing chronic jet lag.
- Circadian rhythms regulate essential physiological functions and biological processes across living organisms.
- Synchronization between the brain's master pacemaker and peripheral clocks is crucial for maintaining health and homeostasis.
- Disruption of circadian rhythms may contribute to the development of various diseases, including cancer.
- Epidemiological studies link night-shift work and chronic jet lag to higher cancer risk.
- Many genes regulated by the circadian clock are involved in processes relevant to tumor development, such as cell cycle control and DNA repair.
- Chronomodulation of chemotherapy has shown promise in improving treatment effectiveness and reducing side effects in cancer patients.
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