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Circadian Clock, Cancer, and Chemotherapy
The body's internal clock, cancer, and chemotherapy
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Abstract
Circadian clock disruption may aid in cancer regression by promoting intrinsic and extrinsic apoptosis.
- The circadian clock significantly influences DNA damage response mechanisms, including DNA repair and cell death processes.
- Epidemiological studies suggest a link between clock disruption and cancer risk, but controlled genetic studies in mice do not support this view.
- In specific genetic contexts, clock disruption could potentially lead to enhanced cancer regression.
- The circadian clock may also impact the effectiveness of cancer treatments by affecting how drugs are processed and how DNA damage is repaired.
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