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A temporal dialogue between the circadian clock and chronic inflammatory diseases
Timing links between the body’s internal clock and long-term inflammatory diseases
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Abstract
Circadian rhythms shape the timing, severity, and tissue specificity of inflammatory responses.
- Cell-intrinsic clocks and external cues regulate immune activity in alignment with daily cycles.
- Chronic inflammation may lead to significant disruptions in circadian rhythms, resulting in a pro-inflammatory state.
- Inflammatory signals from various conditions interact with specific molecular pathways that affect circadian organization.
- Emerging therapies based on circadian principles may offer advantages over traditional anti-inflammatory treatments.
- Future research aims to clarify the connections between circadian clocks, inflammation, and metabolism for targeted interventions.
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