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Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway
Tobacco smoke may disrupt the body’s internal clock, causing lung inflammation and damage through a specific cell pathway
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Abstract
Exposure to cigarette smoke altered clock gene expression and reduced locomotor activity in mice.
- Cigarette smoke exposure increased lung inflammation and caused emphysema in mice.
- The core clock gene BMAL1 was acetylated and degraded in the lungs of mice exposed to cigarette smoke and patients with chronic obstructive pulmonary disease (COPD).
- Disruption of both central and peripheral circadian rhythms was observed following cigarette smoke exposure.
- Targeted deletion of BMAL1 in lung epithelium intensified inflammation in response to cigarette smoke.
- The selective SIRT1 activator SRT1720 did not mitigate the increased inflammation in Bmal1-deleted mice.
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