Disruption of Sirtuin 1–Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease

Expression of core molecular clock proteins is reduced in PBMCs, sputum cells, and lung tissues from smokers and patients with COPD compared to nonsmokers.

• Core molecular clock proteins such as BMAL1, PER2, CRY1, and REV-ERBα show decreased expression in individuals with COPD and smokers.
• SIRT1 levels may be associated with the regulation of the molecular clock and inflammatory responses in the lungs.
• Treatment with the SIRT1 activator SRT1720 may mitigate the reduction of BMAL1 and REV-ERBα in PBMCs from nonsmokers.
• Cytokine release (IL-8, IL-6, and TNF-α) from PBMCs is differentially affected by LPS treatment among nonsmokers, smokers, and COPD patients.
• SRT1720 treatment may inhibit LPS-induced cytokine release in cultured PBMCs.

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