The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation

Pre-treatment with the REV-ERBα agonist GSK 4112 reduced pro-inflammatory cytokine release in response to cigarette smoke extract.

• Cigarette smoke exposure may influence REV-ERBα levels in the lungs, leading to increased inflammation.
• Primary human small airway epithelial cells treated with cigarette smoke extract or lipopolysaccharide exhibited elevated pro-inflammatory cytokines.
• REV-ERBα knockout mice showed a heightened inflammatory response to cigarette smoke, including greater neutrophil influx and cytokine release.
• Specific pro-inflammatory cytokines, such as IL-6, MCP-1, and KC, were significantly increased in REV-ERBα knockout mice after exposure to cigarette smoke.

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