Rev-erbα regulates hepatic ischemia-reperfusion injury in mice

Rev-erbα ablation resulted in higher levels of plasma alanine aminotransferase and aspartate aminotransferase in mice, indicating increased sensitivity to hepatic ischemia-reperfusion injury.

• Mice lacking Rev-erbα exhibited a more severe hepatic ischemia-reperfusion injury, indicated by elevated liver enzyme levels and increased histological damage.
• Higher expression of pro-inflammatory cytokines and increased activation of the Nlrp3 inflammasome were observed in Rev-erbα-deficient mice.
• Pharmacological activation of Rev-erbα reduced liver damage and inflammatory responses associated with ischemia-reperfusion injury.
• The timing of ischemia-reperfusion operations affected liver damage, with operations starting at ZT18 causing more severe injury compared to those starting at ZT6, correlating with Rev-erbα expression levels.
• These findings suggest that Rev-erbα may play a protective role against hepatic ischemia-reperfusion injury through modulation of inflammatory responses.

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