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Atypical patterns of circadian clock gene expression in human peripheral blood mononuclear cells
Unusual daily patterns of internal clock gene activity in human immune cells
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Abstract
Key clock genes PER2 and BMAL1 oscillate in peripheral blood mononuclear cells from healthy humans over a 24-hour cycle.
- Expression of PER2 and BMAL1 was consistent across all subjects, indicating a rhythmic pattern.
- Two distinct groups of subjects displayed significantly different average timing (acrophases) of PER2 and BMAL1 expression.
- BMAL1 and PER2 oscillated together rather than in an expected anti-phasic relationship.
- Constant expression of REV-ERBalpha was linked to the unusual phase relationship of PER2 and BMAL1 in human PBMCs.
- Findings suggest the presence of different chronotypes in clock gene expression patterns in humans.
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