Circadian Variations in Clock Gene Expression of Human Bone Marrow CD34+ Cells

All 7 clock genes were expressed in human CD34-positive hematopoietic cells and whole bone marrow.

• Clock gene expression varies in magnitude between CD34-positive cells and whole bone marrow.
• hPer1, hPer2, and hCry2 exhibit clear circadian rhythms in CD34-positive cells.
• hPer1 shows a circadian rhythm in the whole bone marrow, with peak expression from early morning to midday.
• hBmal1 does not demonstrate a rhythmic expression pattern in either cell population.
• Circadian patterns in serum cortisol, growth hormone, testosterone, and leukocyte counts indicate standardized rhythms among subjects.

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