Circadian expression of clock genes in human peripheral leukocytes

Feb 6, 2007Biochemical and biophysical research communications

Daily rhythms of biological clock genes in human white blood cells

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Abstract

Per1 mRNA exhibits a robust circadian expression in human leukocytes.

  • Circadian rhythms in mammals are regulated by a circadian system.
  • Mouse peripheral leukocytes show circadian oscillations in the expression of clock genes Per1 and Per2.
  • Homozygous Cry1/2 double-deficient mice, lacking a biological clock, display severely blunted rhythms of Per1 and Per2 mRNA expression.
  • Human leukocytes demonstrate varying circadian expression patterns, with Per2 and Bmal1 mRNA showing weaker rhythms compared to Per1.
  • Monitoring Per1 mRNA expression in human leukocytes may provide insights into the circadian system's role in health and disease.

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