Postnatal ontogenesis of molecular clock in mouse striatum

At postnatal day 60, daily oscillations of clock genes in mouse striatum were observed with specific peak times.

• No daily oscillation of clock genes was detected at postnatal day 3.
• At postnatal day 14, significant expression rhythms were identified only for Rev-erb alpha and Npas2.
• At postnatal day 60, Bmal1, Clock, Npas2, and Cry1 showed peak expression at Circadian time (CT) 01, while Per1 peaked at CT 13 and Rev-erb alpha at CT 07.
• Overall mean mRNA levels of most clock genes increased progressively from postnatal day 3 to day 60.
• Cry1 levels were similar at postnatal days 3 and 60 but significantly lower at day 14.

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