The Journal of biological chemistry

The body’s internal clock protein BMAL1 controls cell growth by regulating p21 in liver cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The cell cycle inhibitor p21WAF1/CIP1 is expressed in a circadian rhythm in mouse peripheral organs.

  • Rhythmic expression of p21WAF1/CIP1 mRNA and protein was observed in differentiated skeletal muscle cells after serum shock.
  • In clock-deficient Bmal1-/- mice, p21WAF1/CIP1 expression is significantly increased and loses its rhythmicity.
  • The transcription of p21WAF1/CIP1 is regulated by the opposing actions of specific nuclear receptors involved in the circadian clock.
  • Primary hepatocytes overexpressing p21WAF1/CIP1 showed a reduced proliferation rate.
  • Knockdown of p21WAF1/CIP1 using small interfering RNA reversed the decreased proliferation phenotype.

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